Overall, search engines are getting better every day at understanding what the searcher wants. When approaching your SEO strategy, you should approach every decision with the user in mind. First, establish the foundation of your SEO (ranking and crawling) so search engines can find your content and serve it to the user. Then, focus on improving your site’s technical infrastructure (speed, accessibility, mobile, etc) to improve the user experience on your site. Finally, write content to solve for users’ intent. The days of forcing your way to the top of a search result with keyword stuffing are over. It’s the decade of the searcher. 
As I had a teacher at school who was always really picky on how to draw conclusions I must say that the conclusions you drew for your health situation might be true, but dangerous. For example: If slightly more women than men suffer from health deseases it could be wise to write the information toward women. But, if you take search behaviour into account thing could look a lot different: It might turn up that men search more than women or that (senior) men are more present on the net than women.
Start obsessing over search from your users’ point of view. Drill into their intent. Historically, the name of the SEO game was finding the intersection where high volume and low competition keywords meet. That is still true, but the beauty of the improvements in natural language processing (NLP) is our ability to find pockets of intent around those keywords. 
Brian , your every post is like a book, I always read your post and try to find a few questions to ask .. but to be honest your posts are that comprehensive that, I don’t find a question to ask because you left nothing unexplained ! I wonder how long you take to prepare a post like this, I probably would take a whole year ! 🙂 Good luck Brian. you are a magician of IM strategies.

Brian. You talk about how all these variables matter in getting this article to rank #1 for “list building” and how competitors have way more links than you, but then you also consider your DA and your PA together, you have almost the highest score out of the top 10 rankings; and when you consider you are more topical authority, then that explains why Hugpages (all purpose site) is not ranking higher. Maybe its not all as complicated as you suggest.
Why not? When you skimp on tools, you hinder your marketing from getting better. So, regardless of whether you choose these specific tools or not, make it your goal to find tools that you use regularly. Better tools are equivalent to better marketing. Whatever the tool you choose, make sure that you understand it well and that it makes a measurable improvement on your marketing efforts.
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